Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length194 amino acids

Chemical FormulaC992H1573N255O282S8

DescriptionStandard

        MLYLGISEYFFKSASFAYFTTGAFDITLTTKELYKHLIQNPQGIGSLFSQIAELYIMSRPLMVRILTTEPPVINLEPNNFTLNIPASIVMMTKPKNTTEEVIVSMDFMASTSVDLAIFGQRLICSLSLNRFQLSGPESNRSSIEVLRFENILSSILHFGVIPLANARLQQGFPLPNPHQISLVNSEIEVHKVRR
    

Molecular Weight21840.16 Da

Isoelectric Point (pI)6.91

Net Charge (pH 7.0)-0.13

Net Charge (pH 7.4) -0.61

Charge Density (pH 7.0) -0.0007

GRAVY Index0.18

Hydrophobic Moment 0.59

Boman Index0.15

Instability Index49.04

Aliphatic Index 105.52

Aromaticity 0.0928

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7450.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8571.89

LogP -105.64

H-bond Donors 293.0

H-bond Acceptors 294.0

Rotatable Bonds 707.0

Heavy Atoms 1537.0

Ring Count 34.0

Amide Bonds 213.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0328283 VERIFIED: NO

Provenance & Taxonomy

OrganismMonodelphis domestica [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence