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MYP_155310
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Basic Information
Lantibiotic paenibacillin (Bacteriocin)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
30 amino acids
C129H234N36O41S5
Standard
Sequence
ASIIKTTIKVSKAVCKTLTCICTGSCSNCK
Physicochemical Analysis
3105.78 Da
9.27
4.74
4.47
0.1580
0.54
0.59
0.09
19.12
91.00
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1262.48
-17.29
51.0
51.0
107.0
211.0
0.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0355146 VERIFIED: YES
Provenance & Taxonomy
Paenibacillus polymyxa [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ1883
RECORD: Rec_0374436 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 23.3%, E 0.0%, T 36.7%, C 40.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0388891 VERIFIED: YES
Provenance & Taxonomy
Paenibacillus polymyxa [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
N-terminal acetylation; residues 2, 6,7,27 are dehydrated Ser or Thr; residues 11-15 or 25-29 form lanthionines, and residues 17-20, 19-22, 23-26 form beta-methyllanthionines (thioethers) (He X et al 2008 FEBS Lett 582: 2787-92). Recently, M152-P4 was found to share the same sequence. Highly active against S. aureus ATCC 25923 (MSSA), S. aureus ATCC 43300 (MRSA), B. subtilis ATCC 6633, E. faecium NCTC 7171, E. faecium ATCC 51559 (MDR*), E. faecalis ATCC 51299 (anti-VRE), and S. epidermidis MTCC 3615 (MIC 0.39-1.56 uM) (Jangra et al. 2019). Updated 4/2019
Bio-Activity Profile
Antimicrobial
Staphylococcus epidermidis MTCC 3615
0.39-1.56 μM
MIC
PaperIsolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin.
RECORD: Rec_0414640 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
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