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MYP_155227
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Basic Information
SARS-CoV-2-S (1175-1205), IPB04
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
31 amino acids
C152H261N43O52
Standard
Sequence
SVVNIQKEIDRLNEVAKNLNESLIDLQELGK
Physicochemical Analysis
3522.96 Da
4.66
-2.53
-2.75
-0.0816
-0.43
0.70
-0.10
47.84
131.94
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1599.08
-15.99
52.0
50.0
128.0
247.0
0.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0267998 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome coronavirus 2 [Virus]
HR2-derived fusion inhibitor
2697049
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Lys side-chain cholesterol conjugation
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
0.033 μM
IC50
PaperDesign of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity PMID32376627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376627/
RECORD: Rec_0296729 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome coronavirus 2 [Virus]
HR2-derived fusion inhibitor
2697049
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Lys side-chain cholesterol conjugation
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
1.053 μM
IC50
PaperDesign of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity PMID32376627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376627/
RECORD: Rec_0371524 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV PsV
PMID32376627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376627/
RECORD: Rec_0390613 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2 PsV
PMID32376627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376627/
RECORD: Rec_0411537 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Chol
Chol
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 | 293T/ACE2 cells
0.033±0.013 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperDesign of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity. | Zhu Y, Yu D, Yan H, Chong H, He Y. | J Virol. 2020 Jul 1;94(14):e00635-20. | DOI:10.1128/JVI.00635-20 | PMID:32376627 PMID32376627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376627/
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