Peptide Database

Peptide NameSLAY-screened peptide P5238

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H163N23O28

DescriptionStandard

        VAPYGPYTPTIPSSRLYILV
    

Molecular Weight2207.57 Da

Isoelectric Point (pI)8.47

Net Charge (pH 7.0)0.73

Net Charge (pH 7.4) 0.52

Charge Density (pH 7.0) 0.0365

GRAVY Index0.43

Hydrophobic Moment 0.15

Boman Index0.32

Instability Index47.72

Aliphatic Index 112.00

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 784.57

LogP -4.36

H-bond Donors 27.0

H-bond Acceptors 29.0

Rotatable Bonds 59.0

Heavy Atoms 157.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0252304 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/