Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length264 amino acids

Chemical FormulaC1345H2110N334O394S5

DescriptionStandard

        MEKPILKNLNEMLCPIITGEVEALNVNLSTLEVLTKIDNYTLLDYSIIDSPEITENSLDVNFKGTFYPLENLVDPPFSPAPFVLPERSDSMLYIGISEYFFKSASFAYYTAGAFDVTFSTKEISNHLIQNSQGLGNVLSRVASTSVGLVILGQRLICSLSLNRFRLSLPEPKRSKIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPYNISFVNSDIEVLQSFLLISTDLRYEASLKQQPSLAGWKDLNLLSGQWQGKPAP
    

Molecular Weight29423.47 Da

Isoelectric Point (pI)5.04

Net Charge (pH 7.0)-6.31

Net Charge (pH 7.4) -6.72

Charge Density (pH 7.0) -0.0239

GRAVY Index0.07

Hydrophobic Moment 0.63

Boman Index0.14

Instability Index50.28

Aliphatic Index 108.18

Aromaticity 0.0985

Extinction Coeff. Reduced 24410.00

Extinction Coeff. Oxidized 24535.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0138126 VERIFIED: NO

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyBPI

Tax ID9986

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence