Peptide Database

Peptide NamePore-forming peptide ameobapore C (EH-APP; Parasite, amoebozoa, protozoa, protists)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Standard StatusStandard

Sequence Length77 amino acids

Chemical FormulaC360H610N86O106S6

DescriptionStandard

        IPVLCPVCTSLVGKLIDLVLGGAVDKVTDYLETLCAKADGLVETLCTKIVSYGIDKLIEKILEGGSAKLICGLIHAC
    

Molecular Weight8031.60 Da

Isoelectric Point (pI)5.12

Net Charge (pH 7.0)-2.20

Net Charge (pH 7.4) -2.57

Charge Density (pH 7.0) -0.0286

GRAVY Index0.86

Hydrophobic Moment 0.74

Boman Index0.31

Instability Index24.60

Aliphatic Index 142.99

Aromaticity 0.0260

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3006.16

LogP -21.32

H-bond Donors 109.0

H-bond Acceptors 111.0

Rotatable Bonds 271.0

Heavy Atoms 558.0

Ring Count 5.0

Amide Bonds 76.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0427231 VERIFIED: YES

Provenance & Taxonomy

OrganismEntamoeba histolytica [Protist]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Disulfide5-77; 8-71; 35-46

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Antibiotic

TargetGram-positive bacterium: Micrococcus luteus

Activity5 μM

MethodMIC

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