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MYP_154815
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Basic Information
Phylloseptin-5 (PS-5; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
19 amino acids
C92H149N25O24
Standard
Sequence
FLSLIPHAINAVSAIAKHS
Physicochemical Analysis
1989.32 Da
8.76
0.93
0.63
0.0491
0.92
0.48
0.40
7.96
138.95
0.0526
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
765.49
-6.25
26.0
27.0
62.0
141.0
4.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0054439 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa oreades [Animal]
Phylloseptin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiprotozoal
Trypanosoma cruzi
4.9 μM
IC50
PaperPubMed PMID: 15752569 PMID15752569 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15752569/
RECORD: Rec_0073376 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PMID16963159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16963159/
RECORD: Rec_0159987 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0162848 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa oreades [Animal]
Phylloseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiprotozoal
PaperJ.R.S.A. Leite et al. / Peptides 26 (2005) 565-573. Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus Evidence URLhttps://www.uniprot.org/uniprotkb/P84570/entry
RECORD: Rec_0226480 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa oreades [Animal]; Phyllomedusa hypochondrialis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic
Trypanosoma cruzi
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