Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2333H3780N604O669S19

DescriptionStandard

        MSLHCQLILVLFIAVASATNPGVKVKLTEKGLEYGRQLGMASIQQKLKTIKVPDISGKERVPPIGKVEYSLSHMQIVKLGLPKSAVDLVPGTGIKLSISNAYISLHGNWRVKYLRIIKDSGSFDLNVNGLTITSSLAIKSDETGRPTVSSVSCVATVGSVSIKFHGGASWLYNLFKNFIDKALRNALQKQICPLVADAVNELNPHLKTLNVLAKVDQYAEIEYSMVSSPTVSKSSIDLNLKGEFYNIGKHQEAPFSPTAFSLPPQNDDMLYMGMSAYSVNSAAFVYNKAGALSLYITDDMIPQSSPIRLNTRTFGTFIPEISKRFPGLMMKLLVQTVKTPVITFQPNNATTQASCTVTAYAIQPNSTLSPLFILNLETSVSAQVFISGMRVAGAVSLNKMDLTLRTSYVGEFKVRSLDNILQMVLKVVVIPKLNVQLAKGYPLPAIGKMKLVKTQLKVLKDYMLIGTDVQFTG
    

Molecular Weight51603.85 Da

Isoelectric Point (pI)9.59

Net Charge (pH 7.0)18.99

Net Charge (pH 7.4) 18.30

Charge Density (pH 7.0) 0.0401

GRAVY Index0.14

Hydrophobic Moment 0.77

Boman Index0.13

Instability Index33.52

Aliphatic Index 104.65

Aromaticity 0.0740

Extinction Coeff. Reduced 34840.00

Extinction Coeff. Oxidized 35090.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0065476 VERIFIED: NO

Provenance & Taxonomy

OrganismParalichthys olivaceus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence