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MYP_154668
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Basic Information
Unnamed
Annotation / Sequence feature ▸ Secretory pathway ▸ Secreted protein
Cardiovascular
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Reproductive biology ▸ Reproductive modulation
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Angiogenic
Standard
10 amino acids
C62H89N17O14
Standard
Sequence
DRVYIHPFHL
Physicochemical Analysis
1296.48 Da
6.92
-0.07
-0.37
-0.0065
-0.20
0.34
0.09
22.64
107.00
0.2000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
493.22
-1.12
17.0
16.0
37.0
93.0
5.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0138560 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Angiotensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
Hormonal Cardiovascular
Primary endothelial cells + fetal calf serum 20%
Radioimmunoassay
0.6 min
PaperAn in vitro system for study of effects of angiotensin I on cultured endothelial cells
RECORD: Rec_0158818 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive Cell-Cell Communication Drug Delivery Vehicle Blood-Brain Barrier
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0169593 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
serpin family
10116; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone serpin family Growth factor signaling Angiogenic
PaperPDB 1SMR structural record; X-ray; 2.00 A; chain B/D/F/H; residues 6-9
RECORD: Rec_0175365 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Angiotensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
Hormonal Cardiovascular
Primary endothelial cells + fetal calf serum 5% + ACE inhibitor MK422
Radioimmunoassay
8.3 min
PaperAn in vitro system for study of effects of angiotensin I on cultured endothelial cells
RECORD: Rec_0176848 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Angiotensin
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
1:Beta-decarboxylated aspartate
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Growth regulation Development regulation Receptor modulation
Experimental: 1 hours; /3600 seconds; Mammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Angiotensin-1 (Homo sapiens): PMID 4300938##22186872 PMID4300938;22186872 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4300938/
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