Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2306H3728N604O660S19

DescriptionStandard

        MALSLLLVLLAVVSTTLSMNPGVTVRLTNKGLQYGKQLGMDALQGQLKSVQIPDFSGSQRVSPIGKVKYSLTNIRLVNVGLPKSAVDLVPGTGVKLTIGDAFMNLHGNWRVKYLRIIKDSGSFDVGVTGLSISTTVAVKSDQTGRPVVSSTNCVANVASAKVKFHGGASWLYNLFSKFINKALRNALQKQICPLVDKTVAGLNPKLKTLNVLAKVDKYAEIEYSMVSSPAISQATLDLNMKGEFYNIGKHQEAPFTPAAYSLPSENNNMLYMALSAFTANSAGFVYNKAGVLSLYVTDDMVPKGSPFRLNTKTFGIFIPEIAKQYPGLMMKLLVRAEQNPTVTFQPKNATVQANAMVTAYAIQPNGTLSPLFVLNLESSVSANVFVRELNVAGRLTLNQMKLSLGTSYVGQFDVGSLDSVLRMVLKVVVIPIVNVQLGKGYPLPALGKMNLVNPQLQIMKDYMLIGTDVQFTG
    

Molecular Weight51083.15 Da

Isoelectric Point (pI)9.73

Net Charge (pH 7.0)19.74

Net Charge (pH 7.4) 19.24

Charge Density (pH 7.0) 0.0417

GRAVY Index0.18

Hydrophobic Moment 0.83

Boman Index0.15

Instability Index29.79

Aliphatic Index 103.59

Aromaticity 0.0761

Extinction Coeff. Reduced 34840.00

Extinction Coeff. Oxidized 34965.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0162417 VERIFIED: NO

Provenance & Taxonomy

OrganismCyprinodon variegatus [Bacterium]

FamilyBPI

Tax ID28743

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence