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MYP_154457
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Basic Information
Hymenochirin-1Pa [D9k]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C138H255N37O34S
Standard
Sequence
LKLSPKTKKTLKKVLKGAIKGAIAIASMA
Physicochemical Analysis
3008.79 Da
10.85
7.75
7.54
0.2673
0.25
0.70
0.06
-0.21
121.38
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1158.41
-8.65
41.0
43.0
110.0
210.0
1.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0313619 VERIFIED: YES
Provenance & Taxonomy
skin secretions of the frog Pseudhymenochirus merlini [Animal]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
k=D-Lys
Bio-Activity Profile
Antimicrobial Anticancer
A549
2.5±0.3 μM
LC50
PaperPubMed PMID: 25241629 PMID25241629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25241629/
RECORD: Rec_0322459 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus epidermidis T6/19
1.25 μM
MIC
PMID25241629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25241629/
RECORD: Rec_0325933 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Acinetobacter baumannii NM35
2.5 μM
MIC
PMID25241629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25241629/
RECORD: Rec_0331625 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human umbilical vein endothelial cells HUVEC (IC50 at 6.5+-0.2 microM, Human umbilical vein endothelial cells HUVEC (IC50 at 9.3+-0.3 microM
50 μM
Hemolysis
PMID25241629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25241629/
RECORD: Rec_0337138 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus epidermidis RP62A
1.25 μM
MIC
PMID25241629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25241629/
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