Peptide Database

Peptide NameSLAY-screened peptide P4559

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC110H150N28O32S

DescriptionStandard

        NDHYVPIHPGYCDPFDTYRV
    

Molecular Weight2408.60 Da

Isoelectric Point (pI)5.13

Net Charge (pH 7.0)-2.08

Net Charge (pH 7.4) -2.40

Charge Density (pH 7.0) -0.1038

GRAVY Index-0.82

Hydrophobic Moment 0.32

Boman Index-0.01

Instability Index51.05

Aliphatic Index 48.50

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 945.02

LogP -6.99

H-bond Donors 32.0

H-bond Acceptors 33.0

Rotatable Bonds 66.0

Heavy Atoms 171.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0127742 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/