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MYP_154430
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Basic Information
Beta-defensin 8 (BD-8, mBD-8; Defensin, beta 8; Rodents, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
35 amino acids
C161H266N52O45S6
Standard
Sequence
NEPVSCIRNGGICQYRCIGLRHKIGTCGSPFKCCK
Physicochemical Analysis
3842.55 Da
9.15
4.79
4.44
0.1368
-0.21
0.48
-0.07
47.91
64.00
0.0571
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1575.07
-18.90
61.0
57.0
127.0
264.0
5.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0292467 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]; Mammalia [Animal]
10090; 40674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0305843 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
PaperStructure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.
RECORD: Rec_0346726 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
beta-defensin family
10090; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
6-33; 13-27; 17-34
Bio-Activity Profile
Antimicrobial beta-defensin family Antibacterial Host defense Defensin-like
PaperPDB 1E4R structural record; NMR; chain A; residues 1-35
RECORD: Rec_0357190 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
PaperPubMed PMID: 11714914 PMID11714914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11714914/
RECORD: Rec_0362479 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
PaperBeta-defensin 8 Evidence URLhttps://www.uniprot.org/uniprotkb/Q91V82/entry
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