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MYP_154430
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Basic Information
Beta-defensin 8 (BD-8, mBD-8; Defensin, beta 8; Rodents, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
35 amino acids
C161H266N52O45S6
Standard
Sequence
NEPVSCIRNGGICQYRCIGLRHKIGTCGSPFKCCK
Physicochemical Analysis
3842.55 Da
9.15
4.79
4.44
0.1368
-0.21
0.48
-0.07
47.91
64.00
0.0571
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1575.07
-18.90
61.0
57.0
127.0
264.0
5.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0189418 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
B.cepacia
PaperBeta-defensin 8 Evidence URLhttps://www.uniprot.org/uniprotkb/Q91V82/entry
RECORD: Rec_0215036 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0220915 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 11.4%, E 20.0%, T 34.3%, C 34.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0241742 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PaperPubMed PMID: 11714914 PMID11714914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11714914/
RECORD: Rec_0247449 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa
PaperBeta-defensin 8 Evidence URLhttps://www.uniprot.org/uniprotkb/Q91V82/entry
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