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MYP_154413
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Basic Information
Proteinase inhibitor PSKP-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibiotic activity
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibition of prolyl endopeptidase
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
58 amino acids
C299H482N80O82S6
Standard
Sequence
VIEPKCYKYEGKKCPPDINPVCGTDKRTYYNECALCVFIRQSTKKADKAIKIKKWGKC
Physicochemical Analysis
6701.90 Da
9.34
7.67
7.34
0.1322
-0.72
0.66
-0.19
37.55
60.52
0.1034
11460.00
11835.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2653.60
-22.16
97.0
96.0
226.0
467.0
11.0
60.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0056724 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Proteinase
Structure & Mods
Linear cysteine-rich peptide scaffold with intramolecular disulfide potential [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Hemagglutinating Inhibition of prolyl endopeptidase
PaperL.G. Gebhard et al. / European Journal of Biochemistry 271 (2004) 2117-2126. A Kazal prolyl endopeptidase inhibitor isolated from the skin of Phyllomedusa sauvagii Evidence URLhttps://www.uniprot.org/uniprotkb/P83578/entry
RECORD: Rec_0125948 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Protease inhibitor Enzyme Inhibitor Non-hemolytic
No Target Organism Found
PMID15153102 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15153102/
RECORD: Rec_0143232 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
3 μM
EC50
PMID15153102 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15153102/
RECORD: Rec_0150538 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
3 μM
EC50
PaperPubMed PMID: 15153102 PMID15153102 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15153102/