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MYP_154397
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Basic Information
Cp-thionin II
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
46 amino acids
C218H356N68O62S10
Standard
Sequence
KTCMTKKEGWGRCLIDTTCAHSCRKYGYMGGKCQGITRRCYCLLNC
Physicochemical Analysis
5242.23 Da
9.20
6.76
6.38
0.1470
-0.44
0.51
-0.15
42.06
44.57
0.0870
9970.00
10470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2137.84
-24.19
87.0
80.0
177.0
358.0
6.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0107715 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
128 μg/mL
MIC
PaperPubMed PMID 16824043 | PubMed PMID 27208120 | Lactobacillus brevis L1055: 12.7 ?g/ml|Pediococcus dextrinicus DSM 20293: 10.7 ?g/ml|Staphylococcus aureus Newman: >40 ?g/ml|Bacillus cereus NCIMB 1526: >40 ?g/ml|Salmonella typhimurium SL1344: >40 ?g/ml|Escherichia coli MG1655: >40 ?g/ml|Pseudomonas aeruginosa NCIMB 950: 21.4 ?g/ml | Food Microbi 2018 PMID16824043;27208120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16824043/
RECORD: Rec_0184555 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial
Ralstonia solanacearum
PaperPubMed PMID 16824043 | PubMed PMID 27208120 | Lactobacillus brevis L1055: 12.7 ?g/ml|Pediococcus dextrinicus DSM 20293: 10.7 ?g/ml|Staphylococcus aureus Newman: >40 ?g/ml|Bacillus cereus NCIMB 1526: >40 ?g/ml|Salmonella typhimurium SL1344: >40 ?g/ml|Escherichia coli MG1655: >40 ?g/ml|Pseudomonas aeruginosa NCIMB 950: 21.4 ?g/ml | Food Microbi 2018 PMID16824043;27208120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16824043/
RECORD: Rec_0198700 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design (https://pubmed.ncbi.nlm.nih.gov/18957441/) PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0208665 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas syringae
42 μg/mL
MIC
PaperPubMed PMID 16824043 | PubMed PMID 27208120 | Lactobacillus brevis L1055: 12.7 ?g/ml|Pediococcus dextrinicus DSM 20293: 10.7 ?g/ml|Staphylococcus aureus Newman: >40 ?g/ml|Bacillus cereus NCIMB 1526: >40 ?g/ml|Salmonella typhimurium SL1344: >40 ?g/ml|Escherichia coli MG1655: >40 ?g/ml|Pseudomonas aeruginosa NCIMB 950: 21.4 ?g/ml | Food Microbi 2018 PMID16824043;27208120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16824043/
RECORD: Rec_0237921 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata [Plant]
Defensin; Thionin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Defense peptide Non-hemolytic
No Target Organism Found
PMID16824043 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16824043/
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