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MYP_154395
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Basic Information
[E6K]Hymenochirin-1B
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
29 amino acids
C140H256N38O35S
Standard
Sequence
IKLSPKTKDNLKKVLKGAIKGAIAVAKMV
Physicochemical Analysis
3063.83 Da
10.48
6.75
6.54
0.2329
0.16
0.69
0.03
6.77
124.48
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1198.34
-8.43
41.0
43.0
112.0
214.0
1.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0202352 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
freshly prepared human erythrocytes
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0211945 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
12.5 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0222593 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human colon adenocarcinoma HT29
10.6
LC50
PMID24185042;24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24185042/
RECORD: Rec_0230731 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0239987 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
①Introduction of D-amino acid(s). (Look at 'Stereochemistry')
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis RP62A
1.6 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
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