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MYP_154293
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Basic Information
C41 -X(C41 C teminus-PEG conjugation)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
42 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
EWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0066263 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 42 indicates PEG750-Cys
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of cell-cell fusion between CHO-WT cells and K652 cells
0.0109±0.0022 μM
IC50
PaperPubMed PMID: 22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0167977 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 42 indicates PEG2000-Cys
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of cell-cell fusion between CHO-WT cells and K652 cells
0.0433±0.0148 μM
IC50
PaperPubMed PMID: 22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0187747 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 42 indicates PEG2000-Cys.
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | CHO-WT cells; K652 cells
0.0433±0.0148 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation. | Danial M, van Dulmen TH, Aleksandrowicz J, Pötgens AJ, Klok HA. | Bioconjug Chem. 2012 Aug 15;23(8):1648-60. | DOI:10.1021/bc3002248 | PMID:22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0198198 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 42
Bio-Activity Profile
Antiviral
HIV-1
PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0245229 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 42 indicates PEG750-Cys.
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | CHO-WT cells; K652 cells
0.0109±0.0022 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation. | Danial M, van Dulmen TH, Aleksandrowicz J, Pötgens AJ, Klok HA. | Bioconjug Chem. 2012 Aug 15;23(8):1648-60. | DOI:10.1021/bc3002248 | PMID:22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
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