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MYP_154238
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Basic Information
hEP-4
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
22 amino acids
C113H203N41O30S
Standard
Sequence
CVRLASHLRKLRKRLLRDADDL
Physicochemical Analysis
2648.14 Da
10.79
3.84
3.57
0.1745
-0.53
0.73
-0.45
39.48
128.64
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1196.77
-10.56
46.0
36.0
94.0
185.0
1.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0054197 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
cells
10 μM
IC50
PaperPubMed PMID: 22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0063984 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
Hepatitis C virus (HCVpp) | Huh7.5.1 cells
10 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperHuman apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding. | Liu S, McCormick KD, Zhao W, Zhao T, Fan D, Wang T. | Hepatology. 2012 Aug;56(2):484-91. | DOI:10.1002/hep.25665 | PMID:22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0137664 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0137923 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis C virus (HCV) JFH-1
PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0251033 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Apolipoprotein-derived
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Hepatitis C virus (Virus entry); Huh7.5.1
10 μM
RT-PCR
PaperHuman apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding. | Liu S, McCormick KD, Zhao W, Zhao T, Fan D, Wang T. | Hepatology. 2012 | PMID:22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
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