Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length455 amino acids

Chemical FormulaC2289H3583N613O646S10

DescriptionStandard

        NPGFVVRITQAGLDYAHQQGIAILEKELARLKLPDISGDSRLRHVGKVRYEISSLELQSFNLPYSRISLSPNVGLHISISNAFAEVDGDWRVKLLFIRDHGSFNLNVENVYIKIDLKLGSDTSGKPTVDTSSCSTRISKVRVHFSGKFGWLYNLFYNAVESRFRNILERKVCETVASSVHNDLQPYLRSLPVTARIDAMAGIDYSLVAPPTATAQSLDVELKGEFFSMVHRSAVPFTPLPLALPSDHDHMVYFGASSFFFNTASFAYHAAGALVFEITDSMIPEGVDFHLNTATFSAFVPQLEKMYPDMLMKIRLSTPSAPSLNIGPGGLSLQPVVDVQAYAILPNSSLAPLFLLSLVSNVSAVIDVRSGHIVGNLSVGRLRLFLKHSDVGTFQVRQLQSIMNIFASTILLPHLNGRLEQGFPLPLPDRIQLSNILVRFHQNFLLLGADVHYQPK
    

Molecular Weight50346.30 Da

Isoelectric Point (pI)7.96

Net Charge (pH 7.0)2.17

Net Charge (pH 7.4) 1.05

Charge Density (pH 7.0) 0.0048

GRAVY Index0.12

Hydrophobic Moment 0.65

Boman Index0.13

Instability Index43.03

Aliphatic Index 103.89

Aromaticity 0.0945

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0181709 VERIFIED: NO

Provenance & Taxonomy

OrganismCuculus canorus [Animal]

FamilyBPI/LBP

Tax ID55661

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria