Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length477 amino acids

Chemical FormulaC2467H3829N621O689S15

DescriptionStandard

        MEKKMLKTGYFILLLSCFALQLDANPGLKVRITQKGLDYGWKVGLENIKQEIQNETFQSWSDRENFGLVKFYYTVSGLRMNTVEFPDASVSLIPGTGIKLAIEHASATFHANWSIKTWLVRNHGGATVSLSGVFITVIFQVSRDNKGRLSMLFHNCWLSIHDVKVKLSGGASWVFNLFAGYLKKPIQAYLDKNLCPKIKHKIQRMDAELRTLKVLSQIDAFAQIDYSLINSPAISKTYINLDLKGTVYPAGNRTDPPFVPDPFTLPDKNNSMLYLGVSEYFFKSASLAYYNAGAFNITITKEFSTYFMPTEVTPNSTIPEVLQLVQNYTMSHPLMLTLQSTAAPMISLQTGSLTTEITGYLEMFSVLPNSSLQFIFAGNLTVNTSANMTISKQKLFISLLLKRFHFSLTRSGVDFSEISLLENFLSRVLWNGAIPAINDKLRKGFPLPNQAQTKFIQPVLEFNQGYLLISTDFHYTL
    

Molecular Weight53692.51 Da

Isoelectric Point (pI)9.23

Net Charge (pH 7.0)10.27

Net Charge (pH 7.4) 9.44

Charge Density (pH 7.0) 0.0215

GRAVY Index0.03

Hydrophobic Moment 0.63

Boman Index0.14

Instability Index30.51

Aliphatic Index 95.87

Aromaticity 0.1195

Extinction Coeff. Reduced 65320.00

Extinction Coeff. Oxidized 65445.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296498 VERIFIED: YES

Provenance & Taxonomy

OrganismAlligator mississippiensis [Animal]

FamilyBPI/LBP

Tax ID8496

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria