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MYP_154048
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Basic Information
Gomesin [PYA1TOAC]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
18 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XCRRLCYKQRCVTYCRGR
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0409439 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Latarcin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Salmonella typhimurium
0.8-1.6 μM
MIC
PMID16235231;23426877;17027634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16235231/
RECORD: Rec_0409866 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Latarcin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus
1.6-3.15 μM
MIC
PMID16235231;23426877;17027634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16235231/
RECORD: Rec_0409907 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Latarcin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Klebsiella pneumoniae ATCC 700603
28 μM
MIC
PMID16235231;23426877;17027634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16235231/
RECORD: Rec_0410234 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
2-15, 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer
neoformans
0.8-1.6 μM
MIC
PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757.; Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID10942757;28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/
RECORD: Rec_0413605 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Gomesin
115339
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
2-15, 6-11
Pyroglutamic acid (Z)
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium berghei (gametocyte)
12.5 μM
Percent inhibition; Microscopy (Neubauer hemocytometer)
PaperEffect of the antimicrobial peptide gomesin against different life stages of Plasmodium spp PMID17376436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17376436/
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