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MYP_154048
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Basic Information
Gomesin [PYA1TOAC]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
18 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XCRRLCYKQRCVTYCRGR
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0143616 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Gomesin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Non-standard residue Z at position 1; standardized to X
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperOctober 27, 2000 The Journal of Biological Chemistry, 275,33464-33470. | http://www.jbc.org/content/275/43/33464.full.html
RECORD: Rec_0143652 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Latarcin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus saprophyticus
1.6-3.15 μM
MIC
PMID16235231;23426877;17027634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16235231/
RECORD: Rec_0148033 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Latarcin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
non-canonical residue code at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
16 μg/mL
PMID27331141 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27331141/
RECORD: Rec_0149803 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Latarcin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans MDM8
2.56-5.12 μM
MIC
PMID16235231;23426877;17027634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16235231/
RECORD: Rec_0150070 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Latarcin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Fusarium culmorum
0.4-0.8 μM
MIC
PMID16235231;23426877;17027634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16235231/
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