‹ ›
MYP_154048
← PREVIOUS NEXT → BACK
Basic Information
Gomesin [PYA1TOAC]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
18 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XCRRLCYKQRCVTYCRGR
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0127579 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Latarcin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
non-canonical residue code at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
MIC Escherichia coli
PMID27331141 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27331141/
RECORD: Rec_0127778 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
2-15, 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer
Salmonella typhimurium
0.8-1.6 μM
MIC
PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757.; Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID10942757;28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/
RECORD: Rec_0129307 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Gomesin
115339
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
2-15, 6-11
Pyroglutamic acid (Z)
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium berghei
50 μM
Percent reduction; [3H] Hypoxanthine incorporation assay
PaperAntimicrobial peptide action on parasites PMID22664071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22664071/
RECORD: Rec_0133131 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Latarcin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human malignant melanoma HT-144
PMID16235231;23426877;17027634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16235231/
RECORD: Rec_0134344 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Latarcin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human myelogenous leukemia K562 50% Cell death
2.7
PMID16235231;23426877;17027634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16235231/
FIRST PREV 1 ... 15 16 17 18 19 ... 50 NEXT LAST
Showing 5 records on this page · Page 17 of 50