Peptide Database

Peptide Namekappa-Theraphotoxin-Tb1b

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC176H271N53O53S7

DescriptionStandard

        DDCLGMFSSCDPKNDKCCPNRVCRSRDQWCKYKLW
    

Molecular Weight4201.81 Da

Isoelectric Point (pI)8.32

Net Charge (pH 7.0)1.70

Net Charge (pH 7.4) 1.40

Charge Density (pH 7.0) 0.0486

GRAVY Index-0.99

Hydrophobic Moment 0.52

Boman Index-0.33

Instability Index61.01

Aliphatic Index 30.57

Aromaticity 0.1143

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1753.19

LogP -19.08

H-bond Donors 67.0

H-bond Acceptors 62.0

Rotatable Bonds 137.0

Heavy Atoms 289.0

Ring Count 8.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0143350 VERIFIED: NO

Provenance & Taxonomy

OrganismTheraphosa blondi [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide3-18; 10-23; 17-30

Bio-Activity Profile

Function

Toxin

TargetKv4

RECORD: Rec_0252410 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic