Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length481 amino acids

Chemical FormulaC2412H3773N639O669S11

DescriptionStandard

        MAARSVAVFGVVLDVFLVLTAATNPGFVVRITQAGLDYAHQHGITVLQKELAQLKLPDISGDFPVRHLGKVHYEISSLNLRSFQLPYSRISLVPNVGLHVAISNAFAEVDGNWRVKFHFIRDHGSFDLEVKNVYIKIDLKLGNDASGKPTVSTSACSTRISSVHVHFSGKFGWLYNLFYSAVESRFRKILEGKVCDSVVSSVNGDLQRYLQTLPVTAKIDAKAGIDYSLVAPPAATEQTLDVDLKGEFFSLAHRGAVPFQPPALALPPDHDRMVYFGASSYFFNTAGFAYHAAGALVFEITDSMIPKGVEFHLNTSTFAAFIPQLDKMYPNMLMKLRLSAPSAPFLSITPGGISLQPVADIQAYAILPNTSLAPLFLLSLTGNVSATIDVKSGHIVGKLSVGRMKLSLKHSDVGTFQVRMLQSIMNVYASSILLPRVNERLAEGFPLPLPDRIQLSNILVQFHQNFLLLGADVHYTPRERR
    

Molecular Weight52779.35 Da

Isoelectric Point (pI)9.08

Net Charge (pH 7.0)6.99

Net Charge (pH 7.4) 5.79

Charge Density (pH 7.0) 0.0145

GRAVY Index0.18

Hydrophobic Moment 0.67

Boman Index0.15

Instability Index33.68

Aliphatic Index 102.56

Aromaticity 0.0977

Extinction Coeff. Reduced 33350.00

Extinction Coeff. Oxidized 33475.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0214831 VERIFIED: YES

Provenance & Taxonomy

OrganismGallus gallus [Animal]

FamilyBPI/LBP

Tax ID9031

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria