Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length187 amino acids

Chemical FormulaC923H1459N255O245S9

DescriptionStandard

        PTALPAAHEPMLLLAITEFVANSAAFAYFTAGALRRNISSNMLPRRFPLQLRTKSMGVFSPQLQERYPDQPMELHLSARRQPLLSCHPDALHGALFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITGNRLGGTVSLRGPLCLPHAGLMGLPVPQVKRLETLLKFGLWLFGVPWANSECCPHPVP
    

Molecular Weight20336.60 Da

Isoelectric Point (pI)9.62

Net Charge (pH 7.0)6.46

Net Charge (pH 7.4) 6.02

Charge Density (pH 7.0) 0.0345

GRAVY Index0.14

Hydrophobic Moment 0.57

Boman Index0.14

Instability Index61.86

Aliphatic Index 96.58

Aromaticity 0.0749

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7778.22

LogP -88.57

H-bond Donors 267.0

H-bond Acceptors 266.0

Rotatable Bonds 635.0

Heavy Atoms 1432.0

Ring Count 43.0

Amide Bonds 200.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0372812 VERIFIED: NO

Provenance & Taxonomy

OrganismAptenodytes patagonicus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence