Peptide Database

Peptide NameSARSWW-Vb(1169-1194)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC147H230N36O46S

DescriptionStandard

        AACEVAKNLNESLIDLQELGKYEQYIKW
    

Molecular Weight3269.68 Da

Isoelectric Point (pI)4.59

Net Charge (pH 7.0)-2.21

Net Charge (pH 7.4) -2.42

Charge Density (pH 7.0) -0.0788

GRAVY Index-0.41

Hydrophobic Moment 0.53

Boman Index0.01

Instability Index46.16

Aliphatic Index 104.64

Aromaticity 0.1071

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1362.42

LogP -9.74

H-bond Donors 46.0

H-bond Acceptors 45.0

Rotatable Bonds 112.0

Heavy Atoms 230.0

Ring Count 4.0

Amide Bonds 31.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0407913 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV Entry inhibition

TargetSARS-CoV | Vero-E6 cells

Activity30 μM

Method% inhibition

Half-LifeMammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein. | Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF. | Virus Res. 2006 Sep;120(1-2):146-55. | DOI:10.1016/j.virusres.2006.03.001 | PMID:16616792 PMID16616792 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16616792/

FIRST PREV 1 2 3

Showing 1 records on this page Ã‚Â· Page 3 of 3