Peptide Database

Peptide NameSLAY-screened peptide P4876

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H155N29O33S

DescriptionStandard

        YPHCHTKPLYDLEVHTNNSY
    

Molecular Weight2431.64 Da

Isoelectric Point (pI)6.26

Net Charge (pH 7.0)-0.99

Net Charge (pH 7.4) -1.37

Charge Density (pH 7.0) -0.0494

GRAVY Index-1.12

Hydrophobic Moment 0.34

Boman Index-0.08

Instability Index24.98

Aliphatic Index 53.50

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 992.86

LogP -8.98

H-bond Donors 34.0

H-bond Acceptors 36.0

Rotatable Bonds 71.0

Heavy Atoms 172.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0409256 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/