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MYP_153630
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Basic Information
Cathelicidin-PY
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C151H263N47O39S2
Standard
Sequence
RKCNFLCKLKEKLRTVITSHIDKVLRPQG
Physicochemical Analysis
3425.13 Da
10.20
5.83
5.53
0.2009
-0.48
0.73
-0.26
31.55
100.69
0.0345
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1435.28
-12.56
53.0
48.0
121.0
239.0
3.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0368721 VERIFIED: YES
Provenance & Taxonomy
Paa yunnanensis [Animal]
Cathelicidin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-7
Bio-Activity Profile
Antimicrobial Antifungal Anti-inflammatory Anticancer
Gram-positive Staphylococcus aureus ATCC 2592
2.74 μM
MIC
PaperStructure and Function of A Potent Lipopolysaccharide-binding Antimicrobial and Anti-inflammatory Peptide
RECORD: Rec_0369791 VERIFIED: YES
Provenance & Taxonomy
Paa yunnanensis [Animal]
Cathelicidin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-inflammatory
Staphylococcus aureus ATCC 2592
2.74 μM
MIC
PMID23594231 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23594231/
RECORD: Rec_0385616 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 69.0%, C 31.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Antifungal Hemolytic Anti-Gram-positive Anti-Gram-negative
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0391151 VERIFIED: YES
Provenance & Taxonomy
Nanorana yunnanensis [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0424584 VERIFIED: YES
Provenance & Taxonomy
Nanorana yunnanensis [Animal]
cathelicidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23594231 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23594231/
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