Peptide Database

Peptide NameSLAY-screened peptide P4972

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC97H170N32O27S

DescriptionStandard

        ACPRARVIREALLGLIPDER
    

Molecular Weight2248.65 Da

Isoelectric Point (pI)8.29

Net Charge (pH 7.0)0.79

Net Charge (pH 7.4) 0.59

Charge Density (pH 7.0) 0.0396

GRAVY Index0.02

Hydrophobic Moment 0.64

Boman Index-0.13

Instability Index32.12

Aliphatic Index 127.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 958.14

LogP -7.61

H-bond Donors 35.0

H-bond Acceptors 29.0

Rotatable Bonds 73.0

Heavy Atoms 157.0

Ring Count 2.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0111907 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/