Peptide Database

Peptide NameSLAY-screened peptide P4931

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC97H157N41O32

DescriptionStandard

        HLRHSVTTGDTRNHNGHSLRN
    

Molecular Weight2409.54 Da

Isoelectric Point (pI)11.70

Net Charge (pH 7.0)2.11

Net Charge (pH 7.4) 1.70

Charge Density (pH 7.0) 0.1005

GRAVY Index-1.57

Hydrophobic Moment 0.34

Boman Index-0.42

Instability Index37.67

Aliphatic Index 50.95

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1213.46

LogP -19.01

H-bond Donors 44.0

H-bond Acceptors 38.0

Rotatable Bonds 79.0

Heavy Atoms 170.0

Ring Count 4.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0295347 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/