Peptide Database

Peptide NameTemporin-La

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antimicrobial ▸ Antifungal ▸ Fungicidal activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length62 amino acids

Chemical FormulaC333H542N92O95S2

DescriptionStandard

        MFPLKKSLLLLFFLGTINLSFCEEERDVDQDERRDDPGERNVQVEKRLLRHVVKILEKYLGK
    

Molecular Weight7418.56 Da

Isoelectric Point (pI)6.57

Net Charge (pH 7.0)-0.40

Net Charge (pH 7.4) -0.71

Charge Density (pH 7.0) -0.0065

GRAVY Index-0.49

Hydrophobic Moment 0.94

Boman Index-0.17

Instability Index41.58

Aliphatic Index 105.16

Aromaticity 0.0806

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3077.92

LogP -22.25

H-bond Donors 107.0

H-bond Acceptors 98.0

Rotatable Bonds 260.0

Heavy Atoms 522.0

Ring Count 8.0

Amide Bonds 65.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0052989 VERIFIED: NO

Provenance & Taxonomy

OrganismLithobates catesbeianus [Animal]

FamilyTemporin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Amphibian defense peptide Antibiotic Antimicrobial Antifungal Fungicide Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic Non-ribosomal

TargetCandida albicans, Candida, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus suis, Salmonella

MethodQualitative functional evidence