Peptide Database

Peptide NameSLAY-screened peptide P2123

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC108H192N36O24S

DescriptionStandard

        RPCLVIRAALRIRLEFKLRS
    

Molecular Weight2410.97 Da

Isoelectric Point (pI)11.83

Net Charge (pH 7.0)4.75

Net Charge (pH 7.4) 4.53

Charge Density (pH 7.0) 0.2376

GRAVY Index0.25

Hydrophobic Moment 0.59

Boman Index-0.21

Instability Index54.46

Aliphatic Index 141.50

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1000.48

LogP -6.44

H-bond Donors 39.0

H-bond Acceptors 30.0

Rotatable Bonds 82.0

Heavy Atoms 169.0

Ring Count 2.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0205010 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/