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MYP_153125
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Basic Information
B1 (De Novo Synthesis)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
7 amino acids
C26H50N10O8
Standard
Sequence
KKGKGGG
Physicochemical Analysis
630.74 Da
10.30
2.76
2.55
0.3939
-1.90
0.38
-0.37
7.44
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
315.98
-4.78
11.0
11.0
25.0
44.0
0.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0075805 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
①Residue 3 is N-butylglycine. ②Residue 5 and residue 7 are N-1-naphthylmethylglycine. ③Residue 6 is N-4-methylbenzylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
MSSA ATCC 29213
8-16 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0079572 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
①Residue 3 is N-butylglycine. ②Residue 5 and residue 7 are N-1-naphthylmethylglycine. ③Residue 6 is N-benzylglycine resembling Phe
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
32 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0081735 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
①Residue 3 is N-butylglycine. ②Residue 5 and residue 7 are N-1-naphthylmethylglycine. ③Residue 6 is N-benzylglycine resembling Phe
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: MRSP C22963
4 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0086084 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
①Residue 3 is N-butylglycine. ②Residue 5 and residue 7 are N-1-naphthylmethylglycine. ③Residue 6 is N-benzylglycine resembling Phe
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human red blood cells
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0109525 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
①Residue 3 is N-butylglycine. ②Residue 5 and residue 7 are N-1-naphthylmethylglycine. ③Residue 6 is N-4-methylbenzylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
8-16 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
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