Peptide Database

Peptide NameSLAY-screened peptide P1654

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC93H168N32O19

DescriptionStandard

        TGIRLFLRLRAILRRIA
    

Molecular Weight2038.53 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)4.40

Net Charge (pH 7.4) 4.21

Charge Density (pH 7.0) 0.2587

GRAVY Index0.68

Hydrophobic Moment 0.65

Boman Index-0.08

Instability Index78.44

Aliphatic Index 172.35

Aromaticity 0.0588

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 858.65

LogP -4.91

H-bond Donors 34.0

H-bond Acceptors 24.0

Rotatable Bonds 70.0

Heavy Atoms 144.0

Ring Count 1.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0326202 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/