Peptide Database

Peptide NamelytE signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory expression optimization

Enzyme / Catalytic activity ▸ Hydrolase ▸ Protease/Peptidase

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC109H188N28O33S

DescriptionStandard

        MKKQIITATTAVVLGSTLFAGAASA
    

Molecular Weight2450.89 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)1.50

Net Charge (pH 7.4) 1.28

Charge Density (pH 7.0) 0.0599

GRAVY Index0.96

Hydrophobic Moment 0.38

Boman Index0.37

Instability Index15.66

Aliphatic Index 109.60

Aromaticity 0.0400

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 978.23

LogP -11.06

H-bond Donors 35.0

H-bond Acceptors 36.0

Rotatable Bonds 81.0

Heavy Atoms 171.0

Ring Count 1.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0087479 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Aminopeptidase (AP) secretion

TargetBacillus subtilis WB600

Activity24.19 U/mL

MethodAminopeptidase activity assay

PaperGuan C, Cui W, Cheng J, et al. Construction of a highly active secretory expression system via an engineered dual promoter and a highly efficient signal peptide in Bacillus subtilis[J]. New Biotechnology, 2016, 33(3): 372-379. PMID26820123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26820123/