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MYP_152984
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Basic Information
Pardaxin P-1 (Pardaxin Pa1)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
33 amino acids
C157H252N36O47
Standard
Sequence
GFFALIPKIISSPLFKTLLSAVGSALSSSGEQE
Physicochemical Analysis
3395.89 Da
6.28
-0.23
-0.44
-0.0070
0.65
0.50
0.33
39.34
112.42
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1308.51
-12.79
45.0
47.0
111.0
240.0
5.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0114269 VERIFIED: NO
Provenance & Taxonomy
Pardachirus pavoninus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PaperPatent US 2008/0269122 A1 Evidence URLhttps://patents.google.com/patent/US20080269122A1/en PatentUS 2008/0269122 A1
RECORD: Rec_0133338 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperThompson S. A., Tachibana K., Nakanishi K., Kubota I.. Melittin-like peptides from the shark-repelling defense secretion of the sole Pardachirus pavoninus. Science, 233, 341-343, 1986.
RECORD: Rec_0225053 VERIFIED: YES
Provenance & Taxonomy
Pardachirus pavoninus [Plant]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
PaperPubMed PMID: 17737623 PMID17737623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17737623/
RECORD: Rec_0244546 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0279383 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
14 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/9010936/ PMID9010936 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9010936/
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