Peptide Database

Peptide NameSLAY-screened peptide P5398

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC125H158N28O28S

DescriptionStandard

        WVPPYNCIPHPDFFYIHSYH
    

Molecular Weight2532.83 Da

Isoelectric Point (pI)6.25

Net Charge (pH 7.0)-0.99

Net Charge (pH 7.4) -1.36

Charge Density (pH 7.0) -0.0495

GRAVY Index-0.36

Hydrophobic Moment 0.27

Boman Index0.28

Instability Index41.30

Aliphatic Index 53.50

Aromaticity 0.3000

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 844.20

LogP -1.39

H-bond Donors 28.0

H-bond Acceptors 31.0

Rotatable Bonds 64.0

Heavy Atoms 182.0

Ring Count 14.0

Amide Bonds 20.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0298942 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/