Peptide Database

Peptide NameLycotoxin-Pa2a

Function Ontology

Antimicrobial

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length66 amino acids

Chemical FormulaC314H502N94O91S8

DescriptionStandard

        KECIPKHHECTSNKKGCCRGKLFKYKCQCTTVVDQSGEQAERCFCGTATHHKAAELVVGFGKKFLG
    

Molecular Weight7306.44 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)6.03

Net Charge (pH 7.4) 5.49

Charge Density (pH 7.0) 0.0914

GRAVY Index-0.54

Hydrophobic Moment 0.58

Boman Index-0.12

Instability Index32.37

Aliphatic Index 47.27

Aromaticity 0.0758

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3002.75

LogP -33.88

H-bond Donors 112.0

H-bond Acceptors 109.0

Rotatable Bonds 251.0

Heavy Atoms 507.0

Ring Count 10.0

Amide Bonds 69.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0009699 VERIFIED: YES

Provenance & Taxonomy

OrganismPardosa astrigera [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modsin silico mine the venom gland transcriptome library by comparing with known spider genomes for similar AMPs. Sequence analysis: APD analysis reveals that this sequence is most similar (37.5%) to LtTx-1a k: 15%; c: 12%. GRAVY: -0.538; mol Wt: 7306.515; mol formula: C314H503N93O91S8; mol ex coeff: 1990. Chemical modification: four disulfide bonds are predicted: C1âC4, C2âC5, C3âC8, C6âC7

Bio-Activity Profile

Function

Antimicrobial Anti-inflammatory

TargetB. cereus

Activity1 μM

MethodMIC

RECORD: Rec_0073992 VERIFIED: YES

Provenance & Taxonomy

OrganismPardosa astrigera [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modsin silico mine the venom gland transcriptome library by comparing with known spider genomes for similar AMPs. Sequence analysis: APD analysis reveals that this sequence is most similar (37.5%) to LtTx-1a k: 15%; c: 12%. GRAVY: -0.538; mol Wt: 7306.515; mol formula: C314H503N93O91S8; mol ex coeff: 1990. Chemical modification: four disulfide bonds are predicted: C1âC4, C2âC5, C3âC8, C6âC7

Bio-Activity Profile

Function

Antimicrobial Anti-inflammatory

TargetPseudomonas aeruginosa

Activity1 μM

MethodMIC

RECORD: Rec_0284060 VERIFIED: YES

Provenance & Taxonomy

OrganismPardosa astrigera [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modsin silico mine the venom gland transcriptome library by comparing with known spider genomes for similar AMPs. Sequence analysis: APD analysis reveals that this sequence is most similar (37.5%) to LtTx-1a k: 15%; c: 12%. GRAVY: -0.538; mol Wt: 7306.515; mol formula: C314H503N93O91S8; mol ex coeff: 1990. Chemical modification: four disulfide bonds are predicted: C1âC4, C2âC5, C3âC8, C6âC7

Bio-Activity Profile

Function

Antimicrobial Anti-inflammatory

TargetEscherichia coli

Activity1 μM

MethodMIC

RECORD: Rec_0400317 VERIFIED: YES

Provenance & Taxonomy

OrganismPardosa astrigera [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modsin silico mine the venom gland transcriptome library by comparing with known spider genomes for similar AMPs. Sequence analysis: APD analysis reveals that this sequence is most similar (37.5%) to LtTx-1a k: 15%; c: 12%. GRAVY: -0.538; mol Wt: 7306.515; mol formula: C314H503N93O91S8; mol ex coeff: 1990. Chemical modification: four disulfide bonds are predicted: C1âC4, C2âC5, C3âC8, C6âC7

Bio-Activity Profile

Function

Antimicrobial Anti-inflammatory

TargetStaphylococcus aureus

Activity8 μM

MethodMIC