Peptide Database

Peptide NameHR2-38

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC176H298N50O63

DescriptionStandard

        GDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELG
    

Molecular Weight4122.55 Da

Isoelectric Point (pI)4.20

Net Charge (pH 7.0)-4.23

Net Charge (pH 7.4) -4.44

Charge Density (pH 7.0) -0.1112

GRAVY Index-0.19

Hydrophobic Moment 0.70

Boman Index0.02

Instability Index40.87

Aliphatic Index 130.79

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1877.38

LogP -21.01

H-bond Donors 61.0

H-bond Acceptors 59.0

Rotatable Bonds 147.0

Heavy Atoms 289.0

Ring Count 0.0

Amide Bonds 44.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0364970 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilyHR2-derived fusion inhibitor

Tax ID694009

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetSevere acute respiratory syndrome coronavirus

Activity0.0662 μM

MethodIC50

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