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MYP_152666
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Basic Information
HR2-38
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
38 amino acids
C176H298N50O63
Standard
Sequence
GDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELG
Physicochemical Analysis
4122.55 Da
4.20
-4.23
-4.44
-0.1112
-0.19
0.70
0.02
40.87
130.79
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1877.38
-21.01
61.0
59.0
147.0
289.0
0.0
44.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0086535 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
HR2-derived fusion inhibitor
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV isolate WHU
IC50
PaperFollowing the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors PMID15158473 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15158473/
RECORD: Rec_0104841 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
0.0005-0.005 μM
IC50
PaperFollowing the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors PMID15158473 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15158473/
RECORD: Rec_0200566 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV:inhibition of SARS-CoV cytopathic effect in Vero E6 cells ( synthetic HR2-38
0.0005-0.005 μM
IC50
PMID15158473 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15158473/
RECORD: Rec_0204095 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Fusion inhibition
SARS-CoV | E6 cells
0.0662 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperFollowing the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors. | Zhu J, Xiao G, Xu Y, Yuan F, Zheng C, Liu Y, Yan H, Cole DK, Bell JI, Rao Z, Tien P, Gao GF. | Biochem Biophys Res Commun. 2004 Jun 18;319(1):283-8. | DOI:10.1016/j.bbrc.2004.04.141 | PMID:15158473 PMID15158473 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15158473/
RECORD: Rec_0335740 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV
PMID15158473 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15158473/
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