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MYP_152662
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Basic Information
Esculentin-1LTa (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
47 amino acids
C225H388N64O61S2
Standard
Sequence
RISFKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC
Physicochemical Analysis
5030.01 Da
9.94
6.74
6.49
0.1434
-0.07
0.68
0.02
-11.86
107.87
0.0426
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2048.90
-17.96
75.0
70.0
184.0
352.0
3.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0171634 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
480 μM
LD50
Paperhttps://pubmed.ncbi.nlm.nih.gov/22426384/ PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0191347 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
41-47
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus carnosus KHS
1.3 μM
MIC
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0202963 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0270014 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
41-47
Bio-Activity Profile
Antimicrobial Antibacterial
PaperH. Wang et al. / Peptides 30 (2009) 273-282. The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae) Evidence URLhttps://www.uniprot.org/uniprotkb/B9W1P8/entry
RECORD: Rec_0307432 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
41-47
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans ATCC2002
80 μM
MIC
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
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