Peptide Database

Peptide NameEsculentin-1LTa (Frogs, amphibians, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC225H388N64O61S2

DescriptionStandard

        RISFKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC
    

Molecular Weight5030.01 Da

Isoelectric Point (pI)9.94

Net Charge (pH 7.0)6.74

Net Charge (pH 7.4) 6.49

Charge Density (pH 7.0) 0.1434

GRAVY Index-0.07

Hydrophobic Moment 0.68

Boman Index0.02

Instability Index-11.86

Aliphatic Index 107.87

Aromaticity 0.0426

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2048.90

LogP -17.96

H-bond Donors 75.0

H-bond Acceptors 70.0

Rotatable Bonds 184.0

Heavy Atoms 352.0

Ring Count 3.0

Amide Bonds 47.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0003335 VERIFIED: YES

Provenance & Taxonomy

OrganismHylarana latouchii [Animal]

FamilyEsculentin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide41-47

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetBacillus licheniformis X39

Activity10 μM

MethodMIC

RECORD: Rec_0042303 VERIFIED: YES

Provenance & Taxonomy

OrganismHylarana latouchii [Animal]

FamilyEsculentin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide41-47

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetSerratia rubidaea X01

Activity10 μM

MethodMIC

RECORD: Rec_0044230 VERIFIED: YES

Provenance & Taxonomy

OrganismHylarana latouchii [Animal]

FamilyEsculentin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide41-47

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

RECORD: Rec_0064898 VERIFIED: YES

Provenance & Taxonomy

OrganismHylarana latouchii [Animal]

FamilyEsculentin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide41-47

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStaphylococcus aureus ATCC2592

Activity0.6 μM

MethodMIC

RECORD: Rec_0116934 VERIFIED: YES

Provenance & Taxonomy

OrganismHylarana latouchii [Animal]

FamilyEsculentin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide41-47

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

Targethuman erythrocytes

Activity480 μM

MethodLD50

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