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MYP_152657
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Basic Information
Antimicrobial peptide, Dermaseptin B3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
28 amino acids
C127H219N35O32S
Standard
Sequence
ALWKNMLKGIGKLAGQAALGAVKTLVGA
Physicochemical Analysis
2780.38 Da
10.48
3.79
3.60
0.1354
0.66
0.70
0.31
-7.19
125.71
0.0357
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1075.30
-8.13
37.0
37.0
96.0
195.0
2.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0297413 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa burmeisteri [Animal]
Dermaseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ4385
RECORD: Rec_0319903 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
1.3 μM
MIC
PaperS. Charpentier et al. / The Journal of Biological Chemistry 273 (1998) 14690-14697. Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics Evidence URLhttps://www.uniprot.org/uniprotkb/P84926/entry
RECORD: Rec_0335396 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
MCF-7
12 μM
Cytotoxicity assay
PMID9614066 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9614066/
RECORD: Rec_0350594 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Paracoccidioides brasiliensis
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ4509
RECORD: Rec_0354902 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Enterococcus faecalis
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP01678
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