Peptide Database

Peptide NameEfgartigimod alfa

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length227 amino acids

Chemical FormulaC1155H1783N301O346S7

DescriptionStandard

        DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALKFHYTQKSLSLSPGK
    

Molecular Weight25645.78 Da

Isoelectric Point (pI)7.14

Net Charge (pH 7.0)0.25

Net Charge (pH 7.4) -0.42

Charge Density (pH 7.0) 0.0011

GRAVY Index-0.60

Hydrophobic Moment 0.48

Boman Index-0.05

Instability Index42.93

Aliphatic Index 70.26

Aromaticity 0.0969

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37275.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207246 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configcyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Enzyme replacement

TargetCHO

Half-LifeThe terminal elimination half-life of efgartigimod alfa ranges from 80 to 120 hours.[L39496]