Peptide Database

Peptide NameDermaseptin-PP

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Wound healing/Regeneration ▸ Wound healing

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC123H214N32O30S

DescriptionStandard

        ALWKDMLKGIGKLAGKAALGAVKTLV
    

Molecular Weight2653.28 Da

Isoelectric Point (pI)10.18

Net Charge (pH 7.0)3.79

Net Charge (pH 7.4) 3.60

Charge Density (pH 7.0) 0.1458

GRAVY Index0.64

Hydrophobic Moment 0.71

Boman Index0.26

Instability Index-5.24

Aliphatic Index 131.54

Aromaticity 0.0385

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 994.24

LogP -5.29

H-bond Donors 35.0

H-bond Acceptors 35.0

Rotatable Bonds 93.0

Heavy Atoms 186.0

Ring Count 2.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0415243 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa palliata [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsAPD analysis reveals that this sequence is similar (85.71%) to Dermaseptin-B3 L=A=K: 19%; G: 15%. GRAVY: 0.638; mol Wt: 2653.3; mol formula: C123H215N32O30S1; mol ex coeff: 5550. Chemical modification: Reduction of disulfide bonds and alkylation of cysteines indicate that disulfide bonds are important for peptide stability rather than activity

Bio-Activity Profile

Function

Antimicrobial Antifungal Anticancer Wound healing

TargetKlebsiella pneumoniae ATCC 43816

Activity1 μM

MethodMIC

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