MYP_152608
Dermaseptin-PP
Anticancer
Anticancer
▸
Cytotoxic anticancer activity
▸
Cytotoxic
Antimicrobial
Antimicrobial
▸
Antifungal
Toxicity / Safety
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Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Toxicity / Safety
▸
Cytotoxicity
▸
Cytotoxic
Venom / Toxin
▸
General toxin
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Cytotoxic
Wound healing/Regeneration
▸
Wound healing
Standard
26 amino acids
C123H214N32O30S
Standard
ALWKDMLKGIGKLAGKAALGAVKTLV
2653.28 Da
10.18
3.79
3.60
0.1458
0.64
0.71
0.26
-5.24
131.54
0.0385
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
994.24
-5.29
35.0
35.0
93.0
186.0
2.0
25.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0322117
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa palliata [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Anticancer
Cytotoxic
RECORD: Rec_0325211
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa palliata [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals that this sequence is similar (85.71%) to Dermaseptin-B3 L=A=K: 19%; G: 15%. GRAVY: 0.638; mol Wt: 2653.3; mol formula: C123H215N32O30S1; mol ex coeff: 5550. Chemical modification: Reduction of disulfide bonds and alkylation of cysteines indicate that disulfide bonds are important for peptide stability rather than activity
Bio-Activity Profile
Antimicrobial
Antifungal
Anticancer
Wound healing
ed cancer cells H157
1.55 μM
IC50
RECORD: Rec_0351981
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa palliata [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Anticancer
NCI-H157
1.55 μM
IC50
RECORD: Rec_0363089
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa palliata [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Anticancer
U-251MG
2.47 μM
IC50
RECORD: Rec_0402255
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa palliata [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Anticancer
MCF-7
2.92 μM
IC50
Showing 5 records on this page · Page 3 of 4