Peptide Database

Peptide NameCycloviolin B

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxicity

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC120H185N31O41S6

DescriptionStandard

        GTACGESCYVLPCFTVGCTCTSSQCFKN
    

Molecular Weight2910.33 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.30

Net Charge (pH 7.4) -0.59

Charge Density (pH 7.0) -0.0107

GRAVY Index0.39

Hydrophobic Moment 0.29

Boman Index0.18

Instability Index68.27

Aliphatic Index 38.21

Aromaticity 0.1071

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1151.57

LogP -17.09

H-bond Donors 46.0

H-bond Acceptors 47.0

Rotatable Bonds 89.0

Heavy Atoms 198.0

Ring Count 4.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0385878 VERIFIED: YES

Provenance & Taxonomy

OrganismLeonia cymosa [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCyclization

C-TermCyclization

Disulfide4-18; 8-20; 13-25

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0423543 VERIFIED: YES