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MYP_152507
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Basic Information
Cycloviolin B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
28 amino acids
C120H185N31O41S6
Standard
Sequence
GTACGESCYVLPCFTVGCTCTSSQCFKN
Physicochemical Analysis
2910.33 Da
5.96
-0.30
-0.59
-0.0107
0.39
0.29
0.18
68.27
38.21
0.1071
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1151.57
-17.09
46.0
47.0
89.0
198.0
4.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0224919 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-18; 8-20; 13-25
Bio-Activity Profile
Antimicrobial Antiviral
HIV inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells
0.13 μM
EC50
PaperPubMed PMID: 10813905 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10813905;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0232860 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Defensin
341676
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-18, 8-20, 13-25
Disulfide bonds between Cys4 and Cys18, Cys8 and Cys20,Cys13 and Cys25.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
0.13 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0235474 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antiviral Anti-HIV
HIV-1
0.13 μM
EC50
PaperPubMed PMID 10813905 PMID10813905 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0338686 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV
PMID10813905 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0376676 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-18; 8-20; 13-25
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
CEM-SS cells
0.56 μM
IC50
PaperPubMed PMID: 10813905 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10813905;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
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